Cosmelan is a depigmentation treatment based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Cosmelan formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain. Its principal action is the elimination of melanin patches on the face (melasma and chloasma).

Alternative to Cosmelan treatment could be Coolaser, Chemical peel, Blue Light, IPL.

The Cosmelan Depigmentation treatment offers a series of major advantages and benefits compared with other types of depigmentation products found in the market:

• Cosmelan is very effective in all types of melasma
• Rapid and easy depigmenting action
• Compatible with ALL skin types (Fitzpatrick I — VI)
• Light peeling effect
• Rejuvenates the skin
• Treatment can be used all year round
• Beneficial for acne patients
• Does not contain TCA
• High safety margin

Cosmelan Depigmentation treatment action mechanism is based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Cosmelan formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain.

ONE WEEK after starting the Cosmelan Depigmentation treatment, a noticeable significant improvement of the skin is observed! The reduction of the treated blemish is detected and the appearance of new luminous and rejuvenated skin is present. At the end of the Cosmelan Depigmentation treatment, the blemishes start to disappear altogether, so that, although the patient may be able to “locate” the place where the spot was, the truth is that the pigmentation will have disappeared and nobody will be able to see it just by looking at it.

During the first two days of the Cosmelan treatment, the skin may turn red. If the skin is very sensitive, the patient may experience an itching feeling. Slight burning and tightening of the skin is also absolutely normal, especially during the first 24 to 48 hours after starting the treatment.

Cosmelan Depigmentation Treatment Recovery Time

First and second day

During the first two days of the treatment, the skin may turn red. If the skin is very sensitive, the patient may experience an itching feeling. Slight burning and tightening of the skin is also absolutely normal, especially during the first 24 to 48 hours after starting the treatment. To relieve these problems, it is advisable to apply the mesoestetic Hydra-vital factor K whenever necessary.

Reddening of the Skin

The reddening that occurs on the face after applying the mesoestetic Cosmelan 1 treatment is similar to the effects of day-long exposure to the sun in the snow without protection. (Intense reddening in photo type I and II and practically non existent in photo type IV and V)

Flaking

Flaking may occur on all skin types (and more intensely in photo types I and II) between the second and third day. In this case it is advisable to apply the mesoestetic Hydra-vital factor K cream, repeating this every two hours on the day when the flaking is most intense.

Third and fourth day

After the third or fourth day, the skin appears healthy and luminous and the marks begin to fade.

You may experience some discomfort during Cosmelan Depigmentation Treatment, similar to a transient stinging sensation, during the treatment.

Important: it must be known if the patient has undergone any previous treatments, especially with glycolic acid. If confirmed, any treatment, especially Glycolic Acid, must be eliminated at least, one week prior to using Cosmelan Depigmentation treatment.

The Cosmelan Depigmentation treatment initiated at the medical office must be continued at home, on a daily basis, according to the guidelines indicated. The treatment must not be interrupted under any circumstances, during the whole time prescribed. It is completely forbidden to combine the Cosmelan Depigmentation treatment with other depigmentation treatments, as the appearance of undesired effects cannot be guaranteed. Treatment control visits are recommended. 8 days after beginning of treatment, 15 days after, and a follow up visit every month thereafter.